Combinations ; - see below
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Chlorpropamide | Laboratory & Allied Ltd. | Laboratory & Allied Ltd | 250mg | 100 | Tablet | per tablet | KES 55 |
| Dapromide | Dawa Limited | Dawa Limited | 250mg | 100 | Tablet | per tablet | KES 160 |
| Diabenese | Pfizer Global Pharmaceuticals | Surgipharm Ltd | 250mg | 100 | Tablet | per tablet | KES 1651 |
| Dibonis | Cosmos Limited. | Cosmos Limited | 250mg | 28 | Tablet | per tablet | KES 120.00 |
| Dibonis | Cosmos Limited. | Cosmos Limited | 250mg | 112 | Tablet | per tablet | KES 420.00 |
| Wespromide | West Coast Pharmaceuticals Works Ltd | Ray Pharmaceuticals Ltd | 250mg | 100 | Tablet | per tablet | KES 225 |
| Chlorpropamide More info | |
|---|---|
| Mode Of Action | Sulphonylurea -antidiabetics like chlorpropamide act mainly by directly stimulating the release of insulin from functioning beta cells of pancreatic islet tissue. To achieve this, they inhibit the ATP-potassium channels on the beta cell membrane and potassium efflux. This results in depolarization and calcium influx, calcium-calmodulin binding, kinase activation, and release of insulin-containing granules by exocytosis. |
| Drug Indication | Uncomplicated and non-ketonic diabetes mellitus (maturity onset type II diabetes) |
| Precautions | Maintain regular medical monitoring; elderly; barbiturate therapy; dietetic therapy in obese; Addisons disease; and disulfiram-like reactions. |
| Contra-Indications | Diabetes complicated by keto-acidosis; coma; Raynauds disease; pregnancy; gangrene; severe trauma; fever; severe renal/hepatic/thyroid function impairment; juvenile diabetes mellitus; severe and unstable diabetes; severe inflammation. |
| Side Effects | GI disturbances; blood dyscrasia; hypoglycaemia; jaundice; skin rashes; hypersensitivity reactions; headache; dizziness; oedema; hyponatraemia; paraesthesia; photosensitivity. |
| Dosage | 250mg OD initially (max. 500mg daily) taken after breakfast |
| Pregnancy Category | Category C |
| Pregnancy Category Description | Drugs which, owing to their pharmacological effects, or may be suspected of causing detrimental effects on human foetus or neonates without causing malfunctions. These effects may be reversible |
| Drug Category | DRUGS AFFECTING NUTRITION AND METABOLISM |
| Drug Sub-Category | Sulphonylureas |